Ekwesịrị ịgwọ anụ anụ nke sitere na Agkistrodon (agwọ nwere nzọụkwụ ise).

Ekwesịrị iji ọgwụ antihematic gwọọ Venom Snake sitere na Agkistrodon (agwọ nwere nzọụkwụ ise).

Nkọwa dị mkpirikpi:

A na-eme nnwale ụlọ ọgwụ abụọ, nnwale na-achịkwa ebebo na-achịkwa nke ọma.Ihe mmerụ ahụ niile na-agba ọbara site na mbepụ mgbidi afọ na ịwa ahụ afọ.Ihe nrịbama ọgwụgwọ bụ isi bụ mfu ọbara, oge hemostasis na ọnwụ ọbara kwa mpaghara otu.Randomized placebo na ụlọ ọgwụ ule na 180 ikpe nke mmadụ: nkezi nke random kwekọrọ na placebo, 2 u na 3 u otu atọ, na preoperative 15-20 nkeji otu intravenous doses, pụta na-atụ aro nke a abụọ doses na ọbara ọgbụgba, na-agba ọbara oge na Ọbara n'otu n'otu index dị elu karịa placebo, mana ọ nweghị mmekọrịta nzaghachi n'etiti otu abụọ.N'ime ule nchịkwa dị mma, e nwere ndị ọrịa 324 nọ n'òtù nnwale na ndị ọrịa 108 nọ n'òtù njikwa, na otu dose nke 2U ka e nyere n'ime otu nnwale 15-20 nkeji tupu ịwa ahụ site na otu injection intravenous.Enweghị mmeghachi omume ọjọọ ahụrụ na ule ndị dị n'elu.

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Nkọwa ngwaahịa

Mkpado ngwaahịa

Nnyocha egosiwo na agwọ ndị a na-egbu egbu na-ebutekarị nsị na-ekesa ọbara na neurotoxins, nke nwere ike ịkpata coagulation intravascular (DIC) na ọbara ọgbụgba na-esote, ujo na ọtụtụ akụkụ ahụ.Dabere n'usoro ọmụmụ nke toxicology ọbara nke venom agwọ dị n'ebe ndịda Anhui, a chọpụtara na DIC bụ otu n'ime ihe e ji mara ndị ọrịa na-emerụ ahụ agwọ nwere nsị n'oge, bụ nke dị iche na okwu ọdịnala nke DIC.Ya mere, echiche nke "DIC dị ka" ọrịa na ndị ọrịa na-ata agwọ ka akwadoro na nke mbụ na China (1988).Achọpụtara na TLE na FE bụ isi ihe kpatara "DIC like" a (1992).Nke a dị oke mkpa iji kọwapụta njirimara nke mgbanwe ọbara na ndị ọrịa nwere venom agwọ nzọụkwụ ise, ma na-enyekwa usoro ihe ndabere maka itinye ọgwụ mgbochi kpọmkwem iji gwọọ mgbagwoju anya a.

N'ime nyocha maka usoro ọbara ọgbụgba nke nsị agwọ nzọụkwụ ise kpatara, a chọpụtakwara na nsị agwọ a na-emetụta akụkụ atọ nke sistemu hemostatic nke ahụ (ihe na-akpata coagulation, platelet na mgbidi arịa ọbara), n'etiti ya na ọbara ọgbụgba. Toxin na-emetụta kpọmkwem permeability nke capillaries.N'otu oge ahụ, achọpụtara na ọbara ọgbụgba siri ike na ọzịza nke akụkụ ahụ merụrụ ahụ adịghị mfe idozi, bụ nke metụtara nkwụsị nke ọbara nke thoracic duct lymphatic coagulation factor na adịghị ike ngwa ngwa nke lymphatic.N'ime ogologo oge na mmekorita ya na ụlọ ọrụ Qimen Snakebite, nsonaazụ nyocha ndị a bụ isi na etinyere n'ọrụ arụwo ọrụ dị mkpa n'ịhazi usoro ọgwụgwọ maka ịta agwọ nke ọma na ịhụ na nchekwa nke ndị ọrịa na-ata agwọ, wee nweta mmetụta dị ukwuu n'etiti ọha mmadụ.Mmezu nyocha ahụ enwetala nzere Sayensị na Nkà na ụzụ Achievement Award nke Anhui Province, Science and Technology Progress Award of Anhui Province (1993), Ministry of Health (A) Grade Science and Technology Achievement Group Award (1991);Na 1989, ụlọ ọrụ ahụ jikọrọ aka na Wuhan Institute of Biological Products iji mepụta mgbochi monoclonal megide venom thrombin penta agwọ, nke bụ ihe ịga nke ọma mbụ na China.Na 1996, ụlọ ọrụ ahụ jikọrọ aka mepụta ma mepụta ngwaahịa thrombin na Institute of Biological Products and Drugs of Jinan Military Command (Yuwei Drug Approval No. 118004, Patent CN1141951A).