Edenyere Mmetụta Antithrombotic asaa na onyonyo egosipụtara

Etinyere mmetụta Antithrombotic asaa

Nkọwa dị mkpirikpi:

Enwere ụdị protein abụọ dị na venom agwọ, otu n'ime ha kwụ ọtọ. Enzyme nke na-agbaze fibrin (protolysin) bụ nke a na-akpọ fibrin (protolysin) enzyme (Short for plasminase,fi b ri no L yt I cenz YM E, FLE).Na mgbakwunye na fibrin na fibrinogen na-emebi emebi, Enweghị ọrụ nke plasminogen na ahụ mmadụ, enweghị hydrolysis nke ihe ndị ọzọ na-akpata coagulation na akpụkpọ ahụ platelet, nwere mmetụta antithrombotic doro anya.Nke ọzọ bụ site na suppression Prothrombin na-arụ ọrụ iji gbuo oge usoro coagulation na enweghị ọrụ enzyme.

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Nkọwa ngwaahịa

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Ebu ụzọ mepụta enzyme a site na ATODA wdg sitere na isi agwọ Japanese odo-acha akwụkwọ ndụ akwụkwọ ndụ
A tụlere usoro mgbochi nke protin anticoagulant.
E gosiputara nke a site na mmekorita ya na ihe na-achikota IX ma obu clotting factor X na ion calcium
Nhazi nke 1: 1 mgbagwoju anya iji nweta ogologo oge coagulation;Emechaa,
LU et al.Agk I strodona CU
ACFI, ihe na-egbochi ọbara ọgbụgba, dịpụrụ adịpụ na nsị agwọ.Liu Qing
Liang et al.mụọ ihe na-eme ka ọbara ọgbụgba wee chọpụta na AC FI nwere calcium ion
Na ọrụ anticoagulant ya na nhazi oghere jikọtara ya na ion calcium.
N'ikpeazụ, Xu Xiaolong et al.wepụrụ nsị nke agkistrodon halys site na usoro nkewa ka mma
Ihe ọzọ na-eme ka ọ ghara ịchịkọta ọnụ, ACFI I, na ihe mgbochi nke ihe na-eme ka ọ ghara igbochi ya
Nnyocha mmejuputa usoro, chọpụtara na yiri AC FI, bụ ụdị nke abụọ.zaị
Ning et al.kewapụrụ ihe ọhụrụ anticoagulant site na nsị nke agkistrodon agkistrodon
Achọpụtara na enweghị ọrụ fibrinolytic na phospholipase A
Ọrụ na ọbara ọgbụgba.Qian Xiaojiang et al sitere na Hunan mepụtara agkistrodon venom point
E kewapụrụ ihe ndị na-arụ ọrụ Fibrinolytic ma gosipụta ya site na nyocha thrombolytic in vitro
Ọ nwere mmetụta thrombolytic doro anya.Ekewara ịdị ọcha ahụ site na ụzọ chromatographic atọ
Na ọrụ enzyme ka mma nke ukwuu.N'ihi na akụkụ plasminase nwere
Akụkụ ọbara ọgbụgba na-esiri ike ikewapụ yana uru ngwa ụlọ ọgwụ ya apụtaghị ìhè.Li Zhaoyan wdg.
Site na mbọ iji nweta fibrinolytic enzyme na-enweghị ihe mejupụtara ọbara ọgbụgba, nzaghachi ụlọ ọgwụ fibrinolytic
Site na nkwado teknụzụ.Zhou Xianli [18] gosipụtara site na nnwale na
Ma thrombin na fibrinolytic enzyme nke agkistrodon halys venom nwere mmetụta thrombolytic doro anya, ma.
Mmetụta ozugbo nke fibrinolytic enzyme siri ike karịa thrombin.
Ya mere, thrombin bụ thrombolytic ngwa ngwa, na-aga n'ihu recanalization nke arịa ọbara.
Mee ka ohere nke arịa ọbara dị na mpaghara ischemic dịkwuo mma, zere ịmịnye ọbara nke kpatara mgbawa vaskụla.
Cleft, nwere mmetụta dị mma na mmalite mmalite nke thrombosis, ejikọtara ọnụ abụọ