IgY antibody megide ihe nkịtị motif nke metalloproteinases sitere na Agkistrodon acutus venom ka akwadoro na ọrụ ya na ọrụ venom agwọ ka amụrụ [Usoro] Site n'ịtụle usoro nke metalloproteinases dị iche iche sitere na Agkistrodon acutus venom, anyị haziri wee mepụta peptides antigenic nke ukwuu PT2 na PT1. , nke nwere njikọ chiri anya na ọrụ enzyme ha;Ejiri ogige ndị jikọtara ọnụ KLH-PT1 na KLH-PT2 gbanarị ọkụkọ ọgwụ mgbochi iji nweta ọgwụ mgbochi IgY.The titer nke IgY na cross mmeghachi omume e ji mara na venom nke Agkistrodon acutus na Agkistrodon brevius ELISA na Western blot mụrụ na mbụ;N'ikpeazụ, a na-enyocha ọrụ nkwụsị nke IgY site na nyocha ọbara ọgbụgba subcutaneous na ụmụ oke [Nsonaazụ] ELISA na Western blot gosiri na mgbochi KLH-PT1 na mgbochi Agkistrodon acutus venom IgY nwere ike ịgafe na Agkistrodon acutus venom na Agkistrodon brevius venom, na nke ikpeazụ. dị nnọọ ike karịa nke mbụ;Mgbochi KLH-PT2 IgY enweghị mmeghachi omume dị ịrịba ama na Agkistrodon acutus na Agkistrodon brevius venoms in vitro, mana gosipụtara nsi na-egbochi ike na nnwale ọbara ọgbụgba na vivo, ma dị elu karịa nke abụọ mbụ [Nkwubi] IgY mgbochi nwere ike. cross-meghachi omume na ọbara dị iche iche na-ekesa venoms agwọ akwadoro site n'ichepụta antigen peptide nke metalloproteinases na-ekekọrịta, bụ nke tọrọ ntọala maka nkwadebe nke kpọmkwem, ịrụ ọrụ nke ọma, obere nsi na mgbochi nke hemorrhagic agwọ venom antibody.
Oge nzipu: Dec-26-2022