Pharmacokinetics nke thrombin sitere na Agkistrodon acutus na oke

Haemocoagulase Acutus (Halase), hemostatic ọhụrụ na mmepe halase, bụ thrombin dị ka enzyme (TLE) na-arụ ọrụ dị elu nke sitere na venom agwọ nke Agkistrodon acutus.Iji mụọ pharmacokinetics nke Halase, 125Ⅰ-akara radioisotope usoro na radioassay jikọtara na TCA precip-itate ka etinyere na oke.Nsonaazụ gosiri na e jikọtara ụkpụrụ AUC nke ọma na doses n'okpuru ụzọ abụọ ejiri mee ihe, yana ọnụọgụ mmekọrịta bụ 0.999 8 na 0.999 0 n'otu n'otu;Mkpokọta ọgwụ na imeju, splin na obi ruru ọnụ ọgụgụ ya kacha elu mgbe nkeji ise gachara, ebe ọtụtụ n'ime akụkụ ahụ ndị ọzọ rutere ya na nkeji iri atọ, wee jiri nwayọọ nwayọọ belata;na oge ọ bụla, itinye uche na ọgwụ na imeju dị elu karịa nke anụ ahụ ndị ọzọ;A na-ewepụ Halase kpamkpam yana n'ime mmamịrị.% Thrombin sitere na Agkistrodon acutus bụ ụdị thrombin dịpụrụ adịpụ ma dị ọcha site na venom Agkistrodon acutus.Ọ bụ ụdị ọgwụ hemostatic ọhụrụ nke ndị otu anyị mepụtara pharmacokinetics nke thrombin sitere na Agkistrodon acutus na oke bụ usoro 125 I-labeled radioisotope na ọdịda trichloroacetic acid jikọtara ya na nchọpụta redioaktivu.Nsonaazụ gosiri na ụkpụrụ AUC tụrụ site na ụzọ abụọ ahụ nwere njikọ chiri anya na dose ahụ, yana ọnụọgụ mmekọrịta bụ 0.9998 na 0.9990, n'otu n'otu;Ọdịnaya ọgwụ na imeju, splin na obi bụ 5 min kachasị elu mgbe nchịkwa gasịrị, ebe na n'ọtụtụ anụ ahụ ndị ọzọ bụ 30 min kachasị elu mgbe nchịkwa gasịrị, wee jiri nwayọọ nwayọọ belata;N'oge ọ bụla, ọdịnaya ọgwụ na anụ ahụ imeju dị elu karịa nke anụ ahụ ndị ọzọ;Na mgbakwunye, mkpochapụ thrombin nke Agkistrodon acutus zuru oke, ọkachasị site na mmamịrị