Institute of Snake Venom and Snakebite, Southern Anhui Medical College

Ụlọ nyocha nke Wuhu City, Anhui Province

Aha Chinese

ebe

Anhui Province

ụdị

ụlọ akwụkwọ ndị gụchagoro mbụ

ihe

Nsi agwọ na ọnyá agwọ

Mmezu nyocha nke Institute

Okwu mmalite nke Institute

Nnyocha e mere banyere nsị agwọ na ọnya agwọ nke Southern Anhui Medical College malitere n'etiti 1970s, ma bụrụ onye so na Anhui Provincial Snake Wound Cooperation Group n'oge ahụ.N'afọ 1984, n'okpuru nduzi nke Prọfesọ Wen Shangwu, onye isi ngalaba nkuzi na nyocha nke ụmụ akwụkwọ mbụ ahụ na-arịa ọrịa, e hiwere ụlọ ọrụ nyocha nke nsi agwọ na ọrịa agwọ, nke bụ otu n'ime ụlọ ọrụ mbụ na-eme nchọpụta bụ isi na nke etinyere n'ọrụ. na nsị agwọ na China.N'afọ 2007, a kpọgharịrị ụlọ ọrụ nyocha nke Snake Poison na Snakebite Research Institute nke Southern Anhui Medical College, onye isi ugbu a bụ Prọfesọ Zhang Genbao.N'ime afọ 30 gara aga, isi na etinyere nyocha nyocha nke nsị nsị agwọ na-egbu egbu na ndịda Anhui emeela ihe dị mkpa maka igbochi na ịchịkwa mmerụ ahụ agwọ na iji ihe onwunwe anụ ọkụ na China;Agwọ ndị bụ isi na-egbu egbu na ndịda Anhui bụ Agkistrodon acutus (Agkistrodon acutus), Agkistrodon acutus, Cobra, Green Bamboo Leaf Snake, Chromium Iron Head na Bungarus multicinctus, karịsịa Agkistrodon acutus, nke na-emetụta ahụike na ndụ nke ndị ugwu.Nnyocha egosiwo na agwọ ndị a na-egbu egbu na-ebutekarị nsị na-ekesa n'ọbara na neurotoxins, nke nwere ike ime ka ndị ọrịa na-ata ahụhụ site na mgbasa nke intravascular coagulation (DIC) na ọbara ọgbụgba nke abụọ, ujo, otutu akụkụ ahụ na ihe ndị ọzọ dị njọ;Site n'usoro ọmụmụ ihe gbasara ọbara toxicology nke venom nke Agkistrodon acutus (Agkistrodon acutus) nke dị na ndịda Anhui, a chọpụtara na DIC jikọtara ya na agwọ bụ otu n'ime ihe ịrịba ama nke nsi mbụ, ma dị iche na DIC gosipụtara na omenala. echiche.Ya mere, echiche nke "DIC dị ka" ọrịa na ndị ọrịa a tara Agkistrodon acutus bụ nke mbụ tụrụ aro na China (1988), Achọpụtakwara na thrombin dị ka enzyme (TLE) na fibrinolytic enzyme (FE) dị na venom nke Agkistrodon acutus bụ. isi ihe kpatara "DIC ka" (1992).Nke a dị oke mkpa iji dokwuo anya njirimara mgbanwe ọbara na ndị ọrịa nwere Agkistrodon acutus, ma na-enyekwa usoro ihe omume maka itinye ọgwụ mgbochi kpọmkwem iji gwọọ mgbagwoju anya a.N'ime nnyocha gbasara usoro ọbara ọgbụgba nke Agkistrodon acutus venom kpatara, a chọpụtakwara na nsị agwọ a na-emetụta akụkụ atọ bụ isi nke sistemu hemostatic (ihe na-akpata coagulation, platelet na mgbidi arịa ọbara), nke haemotoxin bụ kpọmkwem. na-emetụta permeability nke capillaries.N'otu oge ahụ, a chọpụtara na ọbara ọgbụgba siri ike nke Agkistrodon acutus venom na-egbu egbu na ihe isi ike nke ọzịza nke akụkụ ahụ merụrụ ahụ iji belata bụ ihe metụtara mgbochi nke mgbakwunye lymphatic nke ihe coagulation na duct thoracic na ọnụ ọgụgụ na-adịghị mma nke lymphatic.Mmezu nchọcha ndị a bụ isi na etinyere n'ọrụ ekerewo òkè dị ukwuu na nkwado ogologo oge na ụlọ ọrụ nyocha nke Qimen Snakebite n'ịhazi atụmatụ ọgwụgwọ maka ire agwọ na-egbu egbu na ịhụ na nchekwa nke ndị ọrịa na-ata agwọ, ma nwetakwa mmetụta dị ukwuu n'etiti ọha mmadụ.Mmezu nyocha ahụ ejirila nke ọma nweta nzere Sayensị na Teknụzụ Achievement Award nke Anhui Province, Science and Technology Progress Award of Anhui Province (1993), na (A) larịị Science and Technology Achievement Collective Award nke Ministry of Health (1991);Na 1989, o jikọrọ aka na Wuhan Institute of Biological Products ịzụlite a monoclonal mgbochi megide thrombin dị ka enzyme nke Agkistrodon acutus venom, nke bụ mbụ ihe ịga nke ọma na China;Na 1996, ọ na-ejikọta ọnụ ma mepụta ngwaahịa thrombin (YWYZZ 1996 No. 118004, patent CN1141951A) na Institute of Biological Products and Drugs of Jinan Military Region.

nchọpụta nchọpụta

N'ime afọ ndị na-adịbeghị anya, ụlọ nyocha ahụ ekewapụla ma sachaa ọtụtụ ihe ndị na-emepụta ihe na-edozi ahụ site na nsị crude nke Agkistrodon acutus, Agkistrodon halys na Cobra na ndịda Anhui, dị ka anti hypercoagulable steeti enzymes, protein C activators (PCA).Nnyocha nyocha ekwenyela na ihe ndị a na-arụ ọrụ nwere ike imetụta usoro nhazi nke coagulation, na-emetụta platelet adhesion, nchịkọta ma chebe ọrụ nke sel endothelial vaskụla, ma nwee nnukwu arụmọrụ na obere toxicity anticoagulation na mmetụta thrombolytic, Nke a dị oke mkpa maka mgbochi na ọgwụgwọ. ọrịa thrombotic na mmụba nke hypercoagulability ọbara;N'otu oge ahụ, a chọpụtakwara na PCA sitere na venom agwọ nwere mmetụta kpọmkwem nke igbu mkpụrụ ndụ leukemia K562 na igbochi metastasis nke mkpụrụ ndụ kansa.Atụmanya ngwa ahụike ya sara mbara.Ụlọ ọrụ nyocha ahụ ejirila nke ọma mee ma rụchaa ọtụtụ ọrụ nyocha, dị ka "Mechanism of DIC nke Agkistrodon acutus venom kpatara", "Nchọpụta maka usoro ọbara ọgbụgba nke Agkistrodon acutus venom na anụmanụ kpatara", "Nchọpụta nke agwọ na nchọpụta dị iche iche nke ya. Ezinụlọ agwọ site na usoro ntinye aha enzyme", nke National Natural Science Foundation kwadoro, Ministry of Health, Department of Health and Department of Education of Anhui Province;Ka ọ dị ugbu a, ọrụ ndị a na-emepe emepe gụnyere: "Nchọpụta na Protein Hemorrhagic Anticoagulant nke Agkistrodon acutus", "Nyocha na Usoro Molecular nke Mmetụta PCA sitere na Agkistrodon halys Pallas Venom na Vascular Endothelial Function", "Nyocha na Molecular Biology". PCA sitere na Agkistrodon acutus Venom megide mkpụrụ ndụ Tumor”, yana nkewa na ịdị ọcha nke akụrụngwa analgesic akwara sitere na Cobra Venom.

Ụlọ ọrụ nyocha nke venom agwọ nke South Anhui Medical College nwere ọnọdụ dị mma, akụrụngwa nyocha zuru oke, nhazi otu nyocha nke ezi uche dị na ya, yana ọganihu na-aga n'ihu na ụzọ nyocha na ụzọ ọrụ aka.A na-atụ anya ka ọ rụpụta ihe ọhụrụ na nyocha sayensị, ọzụzụ ndị ọrụ, wdg. Ihe ndị na-eri anụ agwọ dị na ndịda Anhui bara ọgaranya ma dị oke ọnụ ahịa.Ebe a na-ere ọgwụ venom agwọ bụ ọgwụ nwere ikike ọgụgụ isi na China.Nsonaazụ nyocha na ndabere na ntinye nke venom agwọ na ihe ndị mejupụtara ya dị oke mkpa na mmepe nke akụ na ụba agwọ bara ụba na ndịda Anhui na ngwa ụlọ ọgwụ.

Oge nzipu: Nov-11-2022