Mmetụta nke Tumor na-egbochi akụkụ I nke Agkistrodon acutus Venom na Ọrụ Mbugharị nke Selụ Endothelial Vascular

Ebumnuche: Iji hụ mmetụta nke akụkụ mgbochi tumor I nke Agkistrodon acutus venom (AAVC-1) na ọrụ mbugharị nke sel endothelial vein umbilical vein (HUVECs), na ịchọpụta usoro nwere ike ime nke AAVC - Ⅰ na-egbochi. angiogenesis.Ụzọ: A na-emepụta HUVECs na vitro ma mesoo ya na AAVC - Ⅰ (0, 20, 40, 80 μ G / ml) sel ndị a na-agwọ maka 24 h.A na-eji ule nyocha na nyocha ụlọ chemotactic iji hụ mmetụta nke AAVC - Ⅰ na ọrụ mbugharị cell endothelial;Ejiri RT-PCR na Western blot chọpụta mgbanwe nke mRNA na ọkwa protein nke P-selectin na intercellular adhesion factor (ICAM-1) tupu na mgbe ọgwụgwọ ọgwụ gasịrị.Nsonaazụ: E jiri ya tụnyere HU VEC na otu nkịtị, ikike mbugharị nke mkpụrụ ndụ na AAVC - Ⅰ otu ịta ahụhụ belatara ruo ogo dị iche iche, okwu P-selectin na ICAM-1 mRNA belatara nke ukwuu.Mmechi: AAVC - Ⅰ nwere ike igbochi ọrụ mbugharị nke mkpụrụ ndụ endothelial site n'ịchịkwa mRNA na ọkwa protein nke P-selectin na ICAM-1