Iji hụ mmetụta nke akụkụ mgbochi tumor I nke Agkistrodon acutus venom (AAVC-1) na ọrụ mbugharị nke mkpụrụ ndụ endothelial vein nke mmadụ (HUVECs), na ịchọpụta usoro nwere ike ime nke AAVC - Ⅰ na-egbochi angiogenesis.Ụzọ: A na-emepụta HUVECs in vitro na AAVC - Ⅰ (0, 20, 40, 80 μ G / ml) mkpụrụ ndụ a na-agwọ ọrịa ka etinyere maka awa 24.A na-eji ule nyocha na nyocha ụlọ chemotactic iji hụ mmetụta nke AAVC - Ⅰ na ọrụ mbugharị cell endothelial;Ejiri RT-PCR na Western blot chọpụta mgbanwe nke mRNA na ọkwa protein nke P-selectin na intercellular adhesion factor (ICAM-1) tupu na mgbe ọgwụgwọ ọgwụ gasịrị.Nsonaazụ: E jiri ya tụnyere HU VEC na otu nkịtị, ikike mbugharị nke mkpụrụ ndụ na AAVC - Ⅰ otu ịta ahụhụ belatara ruo ogo dị iche iche, okwu P-selectin na ICAM-1 mRNA belatara nke ukwuu.Mmechi: AAVC - Ⅰ nwere ike igbochi ọrụ mbugharị nke mkpụrụ ndụ endothelial site n'ịchịkwa mRNA na ọkwa protein nke P-selectin na ICAM-1
Oge nzipu: Dec-07-2022