Ngwa nke asaa Antithrombotic Agents
Enwere ụdị protein abụọ nwere mmetụta antithrombotic na venom agwọ, otu nwere ike ime enzyme ejikọrọ na fibrinolytic enzyme a na-akpọ fibrinolytic enzyme (plasmine, FLE). hydrolysis nke ihe coagulation ndị ọzọ na akpụkpọ ahụ platelet, nwere mmetụta antithrombotic doro anya.Nke ọzọ bụ site n'igbochi Prothrombin nkwadebe na-arụ ọrụ na-egbu oge usoro coagulation, na ọ dịghị enzyme ọrụ.
Ụdị enzyme a bụ nke mbụ mepụtara Atoda et al Na-atụle usoro mgbochi nke protin anticoagulant, A kwadoro na mmetụta nke coagulation factor IX ma ọ bụ coagulation factor X na calcium ion Forming 1: 1 mgbagwoju anya ogologo oge coagulation;Mgbe e mesịrị, Lu et al.sitere na Agkistrodon acutus na ndịda Anhui Otu ihe na-egbochi ọbara ọgbụgba ACFI dịpụrụ adịpụ na nsị agwọ.Liu Qing Liang et al.chọpụtara na ACFI nwere calcium ion, E gosikwara na ọrụ anticoagulant ya na oghere oghere metụtara calcium ion. Mgbe e mesịrị, Xu Xiaolong na ndị ọzọ kewara venom nke Agkistrodon acutus na Agkistrodon acutus site na mma nkewa usoro ọzọ anticoagulant ihe ACFI I The Nnyocha mmejuputa usoro chọpụtara na ọ dị ka AC FI ma bụrụ nke nke abụọ.Zhai Ning et al.kewapụrụ a ne anticoagulant ihe sitere na venom nke Agkistrodon acutus, na a na-enyocha ihe anụ ahụ na kemịkal ya, wee chọpụta na o nweghị ọrụ fibrinolytic na enweghị phospholipase A 2 ọrụ na ọbara ọgbụgba.Qian Xiaojiang na ndị ọzọ kewapụrụ venom nke Agkistrodon acutus na Hunan Akụkụ fibrinolytic na-arụ ọrụ dịpụrụ adịpụ ma kwenye site na ule thrombolytic in vitro Ọ nwere mmetụta thrombolytic doro anya.Ekewapụrụ Lei Danqing site na ụzọ chromatography atọ na-eme ka ọrụ plasmin dịkwuo mma.N'ihi na akụkụ plasmin nwere akụkụ ọbara ọgbụgba na-esiri ike ikewapụ ya, na uru ngwa ụlọ ọgwụ ya abụghị ihe doro anya.Li Zhaoyan et al Site na mbọ iji nweta fibrinolytic enzyme na-enweghị akụkụ ọbara ọgbụgba na-enye nkwado teknụzụ.Zhou Xianli [18] gosipụtara site na nnwale na Thrombin dị ka enzyme na plasmin sitere na Agkistrodon halys venom nwere mmetụta thrombolytic doro anya, mana mmetụta plasmin kpọmkwem dị ike karịa nke thrombin dị ka enzyme, ya mere, thrombin dị ka enzyme bụ onye na-arụ ọrụ thrombolytic ngwa ngwa, nke na-eme ka recanalization nke arịa ọbara nwayọọ nwayọọ, na-eme ka ntachi obi nke arịa ọbara na mpaghara ischemic, na-adị ndụ na vaskụla rupture nke ọbara perfusion Cleavage na-enwe mmetụta dị mma na mmalite nke thrombosis, na-eji ha abụọ ọnụ, Ọ nwere ike ibelata. usoro onunu ogwu ma nweta mmetụta anticoagulant na thrombolytic.Ngwa nke asaa Antithrombotic Agents E nwere ụdị protein abụọ nwere mmetụta antithrombotic na venom agwọ, otu onye nwere ike ime enzyme ejikọrọ na fibrinolytic enzyme a na-akpọ fibrinolytic enzyme (plasmine, FLE) . Fibrin na fibrinogen na-emebi emebi, enweghị ọrụ nke plasminogen na ahụ mmadụ, enweghị hydrolysis nke ihe ndị ọzọ na-akpata coagulation na akpụkpọ platelet, nwere mmetụta antithrombotic doro anya.Nke ọzọ bụ site n'igbochi Prothrombin nkwadebe na-arụ ọrụ na-egbu oge usoro coagulation, na ọ dịghị enzyme ọrụ.
Ụdị enzyme a bụ nke mbụ mepụtara Atoda et al Na-atụle usoro mgbochi nke protin anticoagulant, A kwadoro na mmetụta nke coagulation factor IX ma ọ bụ coagulation factor X na calcium ion Forming 1: 1 mgbagwoju anya ogologo oge coagulation;Mgbe e mesịrị, Lu et al.sitere na Agkistrodon acutus na ndịda Anhui Otu ihe na-egbochi ọbara ọgbụgba ACFI dịpụrụ adịpụ na nsị agwọ.Liu Qing Liang et al.chọpụtara na ACF nwere calcium ion E gosikwara na ọrụ anticoagulant ya na nhazi oghere metụtara ion calcium.Ka oge na-aga, Xu Xiaolong na ndị ọzọ kewapụrụ nsị nke Agkistrodon acutus na Agkistrodon acutus site na usoro nkewa ka mma ọzọ Ihe mgbochi mgbochi ACFI I Usoro mmejuputa usoro nyocha chọpụtara na ọ dị ka AC FI ma bụrụ nke abụọ.Zhai Ning et al.wepụrụ ihe ọhụrụ anticoagulant na-akpata site na venom nke Agkistrodon acutus, na nyocha nke anụ ahụ na kemịkal ya, wee chọpụta na ọ nweghị ọrụ fibrinolytic na enweghị phospholipase A 2 ọrụ na ọbara ọgbụgba.Qian Xiaojiang na ndị ọzọ kewapụrụ venom nke Agkistrodon acutus na Hunan Akụkụ fibrinolytic na-arụ ọrụ dịpụrụ adịpụ ma kwenye site na ule thrombolytic in vitro Ọ nwere mmetụta thrombolytic doro anya.Ekewapụrụ Lei Danqing site na ụzọ chromatography atọ na-eme ka ọrụ plasmin dịkwuo mma.N'ihi na akụkụ plasmin nwere akụkụ ọbara ọgbụgba na-esiri ike ikewapụ ya, na uru ngwa ụlọ ọgwụ ya abụghị ihe doro anya.Li Zhaoyan et al Site na mbọ iji nweta fibrinolytic enzyme na-enweghị akụkụ ọbara ọgbụgba na-enye nkwado teknụzụ.Zhou Xianli [18] gosipụtara site na nnwale na Thrombin dị ka enzyme na plasmin sitere na Agkistrodon halys venom nwere mmetụta thrombolytic doro anya, mana mmetụta plasmin kpọmkwem dị ike karịa nke thrombin dị ka enzyme, ya mere, thrombin dị ka enzyme bụ onye na-arụ ọrụ thrombolytic ngwa ngwa, nke na-eme ka mweghachi nke arịa ọbara ji nwayọọ nwayọọ, na-eme ka nkwụsị nke arịa ọbara dị na mpaghara ischemic dị elu, ma na-adị ndụ na mgbawa nke vaskụla nke ọbara na-akpata Cleavage nwere mmetụta dị mma na mmalite nke thrombosis, na-eji ha abụọ eme ihe ọnụ.
Ọ nwere ike belata usoro onunu ogwu ma nweta mmetụta anticoagulant na thrombolytic.
Oge nzipu: Ọktoba 19-2022